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siRNA Chemistry needs
Alveus scientist believe that the successful siRNA/RNAi based therapeutics in to the clinic require rational chemical modifications and optimization that my assist better serum stability, selectivity, control immune activation, delivery and long term safety which are current challenges in this filed. Alveus is working towards helping their clients on finding/predicting common modification strategies on a given sequence which could address some of these challenges. Alveus is using recent structural data for rational modifications on a specific region of the siRNA sequence for the design of next generation siRNA therapeutics.



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